Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae
نویسندگان
چکیده
منابع مشابه
[Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae].
Although quinolone resistance results mostly from chromosomal mutations in Enterobacteriaceae, it may also be mediated by plasmid-encoded Qnr determinants. Qnr proteins protect DNA from quinolone binding and compromise the efficacy of quinolones such as nalidixic acid. Qnr proteins (QnrA-like, QnrB and QnrS) have been identified worldwide with a quite high prevalence among Asian isolates with a...
متن کامل[Mechanisms of plasmid-mediated resistance to quinolones].
Quinolone resistance is caused mainly by chromosomal mutations in gram negative bacteria. In 1998, plasmid-mediated resistance to quinolones in clinical isolates was first reported in a Klebsiella pneumoniae strain. Locus qnr (quinolone resistance) was responsible of the quinolone resistance in this plasmid. qnr codes a protein whose function is protect both DNA-girase and topoisomerase IV from...
متن کاملPrevalence of Plasmid-Mediated Quinolones Resistance among Klebsiella pneumoniae Strains Isolated from Hospitals in Borujerd, Iran
ABSTRACT Background and Objective: Klebsiella pneumoniae is one of the most common causes of bacterial infections. Presence of plasmid-mediated quinolone resistance genes causes low level of resistance in K. pneumoniae. This study investigated the prevalence of resistance to quinolones and fluoroquinolones, and the frequency of qnrA, qnrB and qnrS genes amo...
متن کاملEmergence of plasmid-mediated quinolone resistance genes in Enterobacteriaceae isolated from chickens in China.
increase in the number of different qnr-positive serotypes was observed in 2007, although the total number of positive isolates was evenly distributed between 2003 and 2007 (Table 1). The qnrS1 variant was highly prevalent in Salmonella Corvallis supporting the results recently published from Denmark, the Netherlands and the UK. 2,6,8 The Danish study included a restricted set of Salmonella Cor...
متن کاملResistance plasmid families in Enterobacteriaceae.
Bacteria carry extrachromosomal, self-replicating genetic elements called plasmids. A plasmid is defined as a doublestranded, circular DNA molecule capable of autonomous replication. By definition, plasmids do not carry genes essential for the growth of host cells under nonstressed conditions (109). Plasmids have systems which guarantee their autonomous replication but also have mechanisms cont...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2005
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dki245